A new study by Harvard School of Public Health (HSPH) researchers shows that adults who regularly take ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), reduce their risk of developing Parkinson’s disease by about one-third compared with nonusers.“There is no cure for Parkinson’s disease, so the possibility that ibuprofen, an existing and relatively nontoxic drug, could help protect against the disease is captivating,” said senior author Alberto Ascherio, professor of epidemiology and nutrition at HSPH.The study will be published online March 2 in Neurology and is scheduled to appear in the March 8 print issue.Parkinson’s disease, a progressive central nervous system disease occurring generally after age 50, affects at least half a million Americans, according to the National Institute of Neurological Disorders and Stroke. About 50,000 new cases are reported each year, with the number expected to increase as the U.S. population ages. It is hypothesized that ibuprofen may reduce inflammation in the brain that may contribute to the disease. Prior studies showed a reduced Parkinson’s disease risk among NSAIDS users, but most did not differentiate between ibuprofen and other nonaspirin NSAIDs.In the new study, Ascherio, lead author Xiang Gao, research scientist at HSPH and associate epidemiologist in the Channing Laboratory at Brigham and Women’s Hospital, and colleagues analyzed data from nearly 99,000 women enrolled in the Brigham and Women’s Hospital-based Nurses’ Health Study and more than 37,000 men in the Health Professionals Follow-Up Study. The researchers identified 291 cases (156 men and 135 women) of Parkinson’s disease during their six-year follow-up study (1998-2004 in women; 2000-2006 in men). Based on questionnaires, the researchers analyzed the patients’ use of ibuprofen (e.g., Advil, Motrin, Nuprin), aspirin or aspirin-containing products, other anti-inflammatory pain relievers (e.g., Aleve, Naprosyn), and acetaminophen (e.g., Tylenol). (Although not an NSAID, acetaminophen was included because it’s similarly used to treat pain.) Age, smoking, diet, caffeine, and other variables also were considered.“We observed that men and women who used ibuprofen two or more times per week were about 38 percent less likely to develop Parkinson’s disease than those who regularly used aspirin, acetaminophen, or other NSAIDs,” Gao said. “Our findings suggest that ibuprofen could be a potential neuroprotective agent against Parkinson’s disease, however, the exact mechanism is unknown.”These findings raise hope that a readily available, inexpensive drug could help to treat Parkinson’s disease. “Because the loss of brain cells that leads to Parkinson’s disease occurs over a decade or more, a possible explanation of our findings is that use of ibuprofen protects these cells. If so, use of ibuprofen could help slow the disease’s progression,” Gao said.The findings do not mean that people who already have Parkinson’s disease should begin taking ibuprofen, Ascherio said. “Although generally perceived as safe, ibuprofen can have side effects, such as increased risk of gastrointestinal bleeding. Whether this risk is compensated by a slowing of the disease progression should be investigated under rigorous supervision in a randomized clinical trial,” he said.Support for the study was provided by the National Institutes of Health’s (NIH) National Institute of Neurological Disorders and Stroke and the Intramural Research Program of NIH’s National Institute of Environmental Health Sciences.
There’s plenty of space for entertaining. The bathroom has modern fixtures and fittings.Most of the wood used throughout the home has also been recycled.For example, some of the home’s beams came from an old bridge in Tenterfield.It has an open kitchen, living and dining area that flows onto the entertainment balcony, which doubles as the entry.The master bedroom has an ensuite and entry onto the rear entertainment deck while the remaining two bedrooms have built-in wardrobes and share a bathroom with floating bath.There is a large storage area and workshop underneath the house, which also has space for one car.“We use it as a bit of a gym and for storage,” Mr May said.DJ Stringer Property Services principal David Stringer described it in his listing as a “character filled home”. The home is almost hidden behind its tropical garden.“A truly divine property glowing with its attention to detail that feels as though it has been hand plucked from a village in Ubud, minus the rice fields, and delicately inserted within our own cultural setting,” he said.“If you are looking for a character filled home that greets you with a warm personality, then this is one property where Bali can be enjoyed without the need of a passport.” The perfect spot to watch the world go by.ESCAPE to a Balinese retreat in your own backyard. This Coolangatta property resembles a tropical oasis with lush plants and Buddha statues surrounding it.Its relaxed vibe is what made owners John and Maria May fall in love with the three-bedroom home.“(It was) the Bali style of it, it’s a real beach house,” Mr May said.“We were looking for a small house rather than a bigger house too.”They have been living in the property for the past 12 years. The kitchen has a view over the balcony. But it’s also the perfect escape.Mr May said they spent a lot of time outside, especially on the front entertainment balcony, which has a thatched ceiling.“We just sit out the front all the time, it’s got a really nice balcony,” he said.More from news02:37International architect Desmond Brooks selling luxury beach villa16 hours ago02:37Gold Coast property: Sovereign Islands mega mansion hits market with $16m price tag2 days ago“The yard is very private, nobody can see in.”There is also an entertainment deck at the back of the property, which leads to a raised grass area and open firepit.It also has a plunge pool and barbecue area in the front yard.Mr May said despite how it may appear, the garden mostly took care of itself.“It’s really easy to maintain,” he said.“All the plants are easy to maintain and there’s only a little bit of mowing (required).”The home is filled with features that give it character, including timber flooring and French doors. The home is surrounded by tropical trees. Take a dip in the plunge pool. You could get lost in this tropical garden.
They sit bottom of Group E without a win.Chelsea slipped up as well as they drew 1-1 at Maribor.But Jose Mourinho’s men stay top of Group G. Manchester City’s hopes of reaching the Champions League knockout stages are in tatters this morning.They lost 2-1 at home to CSKA Moscow.Yaya Toure and Fernandinho were red carded.