Back to overview,Home naval-today Bidders submit final proposals for Canadian Surface Combatant program View post tag: CSC Three teams of bidders have submitted their final proposals for the construction of a fleet of new frigates for the Royal Canadian Navy under the Canadian Surface Combatant Program.The companies received feedback to revise their proposals in May and the deadline for the final bids to be submitted was Friday last week.A total of 15 CSC ships are expected to be built by Irving Shipbuilding as prime contractor. The government expects to spend between CA$55 billion and 60 billion on the program but a more specific figure will be known once companies submit their reviewed financial bids, which were also due Friday.Canada’s Combat Ship Team – composed of Lockheed Martin, BAE Systems and CAE, MDA, L3 Technologies, and Ultra Electronics – submitted their proposal based on the Type 26 Global Combat Ship which was recently selected by Australia as the preferred design for a multi-billion dollar frigate construction program.“With the UK Type 26 program running ahead of CSC, our Canadian ship will benefit from lessons learned on the UK and Australian programs,” said Anne Healey, BAE Systems country director, Canada.“Canadian companies such as W.R. Davis Engineering in Ottawa, Rolls-Royce in Peterborough and L3 MAPPS in Montréal have already begun work on delivering high-technology systems for the UK’s Type 26, demonstrating the skills and capability available from the Canadian supply chain.”One of the other two bidders is the Alion Science and Technology-led team with a proposal based on the De Zeven Provinciën Air Defence and Command frigate which is in service with the Dutch Navy.“Each decision we made for equipment selection and systems integration focused on delivering cost-effective solutions that meet the requirements while delivering robust Canadian content,” Bruce Samuelsen, chief operating officer for Alion, said in December 2017 when Alion announced its participation in the program. “Many original system suppliers are building systems in Canada, but our combat system partners are actually creating manufacturing jobs for Canadians.”The third bidder is Spanish Navantia with its F-105 frigate design. The company will partner with Saab and CEA Technologies to deliver the ships should it be selected.Italian shipbuilder Fincantieri tried to seal the deal with its FREMM frigate design in an offer outside the tendering process. Fincantieri oferred to build 15 frigates for a fixed price of $30 billion but the government said it would not be accepting the “unsolicited proposal at the final hour”.The Canadian government and Irving Shipbuilding are scheduled to announce the winning proposals by the end of the year with construction starting in early 2020s. The surface combatants will be replacing Canada’s Iroquois-class destroyers and Halifax-class frigates. Authorities Bidders submit final proposals for Canadian Surface Combatant program July 23, 2018 View post tag: Royal Canadian Navy Share this article
Harvard Stem Cell Institute (HSCI) researchers have identified in the most aggressive forms of cancer a gene known to regulate embryonic stem cell self-renewal, beginning a creative search for a drug that can block its activity.The gene, SALL4, gives stem cells their ability to continue dividing as stem cells rather than becoming mature cells. Typically, cells only express SALL4 during embryonic development, but the gene is re-expressed in nearly all cases of acute myeloid leukemia and 10 to 30 percent of liver, lung, gastric, ovarian, endometrial, and breast cancers, strongly suggesting it plays a role in tumor formation.In work published in the New England Journal of Medicine, two HSCI-affiliated labs — one in Singapore and the other in Boston — show that knocking out the SALL4 gene in mouse liver tumors, or interfering with the activity of its protein product with a small inhibitor, treats the cancer.“Our paper is about liver cancer, but it is likely true about lung cancer, breast cancer, ovarian cancer, many, many cancers,” said HSCI Blood Diseases Program leader Daniel Tenen, who also heads a laboratory at the Cancer Science Institute of Singapore (CSI Singapore). “SALL4 is a marker, so if we had a small molecule drug blocking SALL4 function, we could also predict which patients would be responsive.”Studying the therapeutic potential of a transcription factor is unusual in the field of cancer research. Transcription factors are typically avoided because of the difficulty of developing drugs that safely interfere with genetic targets. Most cancer researchers focus their attention on kinases.The HSCI researchers’ inquiry into the basic biology of the SALL4 gene, however, revealed another way to interfere with its activity in cancer cells. The gene’s protein product is responsible for turning off a tumor-suppressor gene, causing the cell to divide uncontrollably. Using this knowledge, the researchers demonstrated that targeting the SALL4 protein with druglike molecules could halt tumor growth. “The pharmaceutical companies decided that if it is not a kinase and it is not a cell surface molecule, then it is ‘undruggable,’ ” Tenen said. “To me, if you say anything is ‘undoable,’ you are limiting yourself as a biomedical scientist.”Earlier this year, Tenen’s co-author, HSCI-affiliated faculty member Li Chai, a Harvard Medical School assistant professor of pathology at Brigham and Women’s Hospital, published a paper in the journal Blood, reporting that a SALL4 inhibitor has similar treatment potential in leukemia cells.Chai took blood samples from patients with acute myeloid leukemia, treated the leukemic cells with the inhibitor that interferes with SALL4 protein activity, and then transplanted the blood into mice. The result was a gradual regression of the same cancer in mice.“I am excited about being on the front line of this new drug development,” Chai said. “As a physician-scientist, if I can find a new class of drug that has very low toxicity to normal tissues, my patients can have a better quality of life.”Chai and Tenen are now working with HSCI Executive Committee member Lee Rubin, the Harvard Institute of Chemistry and Cell Biology, and James Bradner of Dana-Farber Cancer Institute, another HSCI-affiliated faculty member, to overcome the technical challenges of drug development and demonstrate the potential of SALL4 interference to treat other forms of cancer.“I think as academics, we seek to engage drug companies because they can do these types of things better than we can,” Tenen said. “But, also as an academic, I want to go after the important biologic targets that are not being sought after by the typical drug company — because if we do not, who will?”The basic research that explored the biology of SALL4 was financed by a 2007 seed grant from HSCI, with more recent funding provided by a Singapore Translational Research Award from the Singapore National Medical Research Council, and grants from the Singapore Ministry of Education and National Research Foundation, and the National Institutes of Health. Kol Jia Yong, Chong Gao, and Henry Yang, among others, contributed to this work.
The Dutch pensions system has lost part of its attractiveness since the financial crisis, which hurt its large capital-funded second pillar, according to a pensions law professor.Yves Stevens, professor of pensions law at the Catholic University of Leuven in the Belgium, argued in an interview with IPE’s Dutch sister publication Pensioen Pro that the Netherlands’ generous state pension (AOW) was the best feature of the system.He said that it would be very difficult to “export” the second pillar to other European countries because of the current low interest rates and the increasing individualisation of the labour market.Stevens is also a member of the European High Level Expert Group on pensions, which is to advise the European Commission about the improvement of second and third pillar pensions by the end of this year. Yves StevensThe professor argued that the financial crisis had changed the governments’ approach to the so-called ‘Aaron Condition’, which reflects whether supporting pay-as-you-go or capital-funded pension provision is more efficient.If the real interest rate is lower than economic growth, pay-as-you-go is more attractive, he said.“Until the crisis, the Aaron Condition had always favoured capital-funding,” Stevens explained. “However, the low interest rates and [low] return assumptions have made pay-as-you-go more favourable.”According to the professor, the individualisation of the labour market – also known as the ’gig economy’ – had led to a greater variety of types of employment, with fewer fixed contracts and waning trade union power.“As a consequence, the second pillar has come under pressure from the first and third pillars all over Europe,” he explained. “Some countries, including Poland, Romania and Hungary, are reducing their second pillar.”Poland, for example, removed its own government bonds from the second pillar in 2014, transferring them into the first pillar to help fund the state pension.Stevens noted that, where capital-funded plans are being set up, the trend in many countries was towards auto-enrolment, with the option of opting out – as is the case in the UK, Ireland, Poland and Turkey.“But this is all about an individual approach and not about collective labour conditions.”In Stevens’s opinion, the Netherlands should be proud of its state pension arrangement, which is available to all citizens, regardless of their labour history. The only other country where this applied was Iceland, he said.Stevens: “Moreover, the AOW benefits are much higher than in many other countries, including Belgium.“This is a really strong foundation of the Dutch pensions system. As a consequence, there is hardly poverty among the elderly in the Netherlands.” According to Stevens, the perception of capital-funded pensions has changed since the crisis. In Belgium, for example, the Dutch system was no longer viewed as a good example.“Although many sector schemes have been established in Belgium since 2003, they never raised their premiums from 1-2% to the envisaged 4-6%, as the crisis has dented confidence,” he said.“Companies opted for salary and bonuses, rather than investing in a pension fund. As in Belgium, a pension is more considered as salary than as social provision, this choice was easier here.”‘Pay as you go’ versus ‘capital funded’
The league released a statement on June 30 saying it did “not endorse any political organisation or movement, nor support any group that calls for violence or condones illegal activity”. Premier League captains were consulted over the change during a conference call on Thursday.Advertisement Instead of the BLM badge, the players’ shirts will have a new slogan reading “No Room For Racism” when the 2020⁄21 Premier League season starts on Saturday. Premier League chief executive Richard Masters said: “We, our clubs, players and match officials have a long-standing commitment to tackling discrimination. Premier League chief executive Richard Masters Read Also: Liverpool cannot match Chelsea spending power – Kloop “Players rightly have a strong voice on this matter, which we saw last season. We have continued to talk and listen to players on this issue and will support them as well as continuing to emphasise the Premier League’s position against racism.” The league said it would continue to support players who take the knee before matches in solidarity with the BLM movement. FacebookTwitterWhatsAppEmail分享 Loading… Premier League chiefs say Black Lives Matter badges on team shirts will be replaced by patches promoting the organisation’s own anti-discrimination campaign. The badges were worn by players last season following the global protests sparked by the death of George Floyd in the United States at the hands of a white police officer. However, the Black Lives Matter group in Britain has been accused of anti-Semitism and criticised over calls to defund the police. Promoted Content10 Risky Jobs Some Women DoThe 18 Most Visited Cities In The WorldOnly The Chosen Ones Can Appear On-Screen Even After Their DeathCan Playing Too Many Video Games Hurt Your Body?6 Great Ancient Mysteries That Make China Worth Visiting11 Strange Facts About Your Favorite TV ShowsTop Tastiest Foods From All Over The WorldFantastic-Looking (and Probably Delicious) Bread Art6 Interesting Ways To Make Money With A DroneEver Thought Of Sleeping Next To Celebs? This Guy Will Show YouThe Very Last Bitcoin Will Be Mined Around 2140. Read MoreBest & Worst Celebrity Endorsed Games Ever Made
Tiger Woods produced a scintillating finish to win a fifth Masters title and end an 11-year wait to claim a 15th major.There were raucous celebrations around the 18th green as Woods finished with a two-under-par 70 to win on 13 under, one clear of fellow Americans Dustin Johnson, Xander Schauffele and Brooks Koepka.Overnight leader Francesco Molinari’s hopes sunk with two double bogeys on the back nine and he had to settle for a share of fifth on 11 under.Woods, written off by so many so often as he battled back problems in recent years, punched the air in delight, a wide smile across his face, before celebrating with his children at the back of the green.”I’m a little hoarse from yelling,” said the 43-year-old. “I was just trying to plod my way around all day then all of a sudden I had the lead.”Coming up 18 I was just trying to make a five. When I tapped in I don’t know what I did, I know I screamed. “To have my kids there, it’s come full circle. My dad was here in 1997 and now I’m the dad with two kids there.”It will be up there with one of the hardest I’ve had to win because of what has transpired in the last couple of years.”It is the first time Woods has come from behind in the final round to win a major and it his first Masters victory since 2005.He is now just one behind Jack Nicklaus’ record of six wins at Augusta National and three behind his fellow American’s overall major tally of 18.It caps a remarkable resurgence for Woods, who missed the 2016 and 2017 Masters with his back problems, finally undergoing back fusion surgery in April of that year. A superb 2018 followed where he challenged at The Open before finishing joint sixth and pushed eventual champion Koepka close at the US PGA Championship.He then capped off the season by winning the Tour Championship, his 80th PGA Tour title and this victory puts him one behind the record of 82 held by Sam Snead.
Sophomore guard Zachary Winston of Albion College in Michigan — the brother of Michigan State All-American Cassius Winston — was struck by a train and killed on Saturday night.The Detroit Free Press reported that an Amtrak passenger train with 65 passengers aboard struck a pedestrian running on the tracks through Albion at 8:41 p.m. An Amtrak spokesperson told the Free Press the family of the victim had been notified. Police said ge purposefully stepped in front of the train, per the Free Press. Albion president Dr. Mauri Ditzler acknowledged the loss of Zachary Winston, although chose not to identify him so soon after the accident. Along with a promise to offer grief counseling to the college community and more details later Sunday, he issued a statement.“Last night, our family lost a student. And as families do in difficult times, we must come together to mourn and to embrace one another,” he said. “We have been in close contact with the student’s family and are doing everything we can to support them.“In accordance with the family’s wishes, we are not sharing a name or details at this time. Please keep the family close in your heart.” Zachary Winston, 19, was a product of Detroit Jesuit High (Detroit). He played 15 minutes off the bench and scored three points in Albion‘s season-opening loss to Mount Union on Friday.His brother, Cassius, is a senior for the top-ranked Spartans, a member of the 2019 Sporting News All-America team and the 2019 Big Ten Conference Player of the Year. He led Michigan State to the Final Four last April, its eighth appearance under coach Tom Izzo.MSU is scheduled to play Sunday night against Binghamton in East Lansing.