Pianist Holly Bowling has taken the music of Phish to new heights, transcribing it for piano and performing these stripped-down versions for fans everywhere. Bowling turned heads with her performance of the full “Tahoe Tweezer,” and continues to impress with her unique interpretations of Phish’s improvisations.Of course, Phish’s music isn’t all improvised, and one of the more rigorous compositions by the band is their song “It’s Ice.” Bowling just released an intriguing video for Phish phans, where she talks about the transcription process and performs!Watch Bowling’s new video, streaming below.
17 Views no discussions Sharing is caring! Share Tweet HealthLifestyle Monkey HIV vaccine ‘effective’, say researchers by: – May 12, 2011 Share Share A new vaccine can protect macaques against the monkey equivalent of HIV and could provide a fresh approach to an HIV vaccine, a study suggests.US researchers say the vaccine offered protection to 13 of 24 rhesus macaques treated in the experiment.In 12 of the monkeys, the vaccine was still effective 12 months later.They claim the work, published in the journal Nature, could “significantly contribute” to the development of an effective HIV/Aids vaccine.The researchers gave 24 healthy rhesus macaques a vaccine containing a genetically modified form of the virus, rhesus cytomegalovirus (CMV).The vaccine was engineered to produce antigens to attack simian immunodeficiency virus (SIV), the monkey equivalent of HIV.It was shown to offer complete control against SIV within 13 of the monkeys, with half the monkeys still protected a year on.The vaccine worked by stimulating the production of a particular type of blood cell, called “effector memory T-cells”, which can remain vigilant in the body long after an infection has abated, providing long-term protection.Lead author Professor Louis J Picker, of the Vaccine and Gene Therapy Institute in Oregon, compares these cells to armed soldiers at the ready.“There are soldiers that are back at the base with their rifles in the shed, and then you have the guys out in the field,” he told the BBC.There was also evidence, he said, that the vaccine all but eradicated traces of SIV in the monkeys, something which he said was “unprecedented” in HIV vaccine research.Safety concernsResearchers in the field welcomed the research, but said safety issues would need to be addressed before similar approaches could be tried in humans.“I’m excited by the science because it really does demonstrate that it may be possible to eradicate the HIV virus by a strong immune response,” said Professor Sir Andrew McMichael of Oxford University.“But at the same time I’m scratching my head how to take this approach into humans.”Professor McMichael said HIV arose from a type of SIV found in chimpanzees, so the animal model used in the study was a good one. The problem, he said, was the potential safety and regulatory issues with introducing CMV into humans, even though many of us already carry the virus.“CMV is not totally benign, it does cause a number of diseases. If you’re giving people something you’re not going to be able to get rid of should it cause problems, then that’s quite a difficult risk to manage.”Professor Robin Shattock of Imperial College, London, agreed safety would be key.“The breakthrough here is in using a viral-delivered vaccine that persists – essentially using an engineered virus to thwart a pathogenic virus. The tricky part will be showing it is safe and effective in humans.”Professor Picker responded by saying such issues would be addressed in forthcoming work, pointing out that early forms of the smallpox vaccine also carried health risks to humans.“On one level 99% of people in sub-Saharan Africa are CMV-positive and half the people in the developed world are, so we know at lot about it and it’s mostly non-pathogenic, except in vulnerable populations like pregnant women,” he said.“We’re fully aware to make it available to humans, then the next step is to make a virus which retains or has an enhanced ability to make effector memory cells, but no longer has the capacity to infect vulnerable parts of the population.”Vaccine failureDeveloping an HIV vaccine has so far proved a deeply challenging task, but there have been some promising results.In 2009, researchers in Thailand published in the Lancet the results of an experimental HIV vaccine, which they said reduced by nearly a third the risk of contracting HIV.Then last year, a study in the New England Journal of Medicine suggested a drug used to treat HIV-positive patients may offer gay and bisexual men some protection against contracting the virus.Trials of the combination drug Truvada among nearly 2,500 men suggested it could reduce the chances of male-to-male HIV infection by 44%.But major breakthroughs remain hard to come by. Indeed, the new Nature study comes as a separate paper in The Lancet Infectious Diseases reports on the failure of an HIV vaccine trial in South Africa.The MRKAd5 HIV-1 vaccine was trialled in a study involving 801 patients, and no evidence was found that the vaccine was effective.However, the report authors concede that the study’s conclusions may have been compromised by a premature end to the trial.BBC News
Greensburg, IN—On Tuesday, September 17, troopers from the Indiana State Police-Versailles Post began investigating the theft of a large tractor and farm implements from southwest Decatur County. The stolen items were recovered but the investigators are asking for the public’s help in locating the people responsible for the theft.Troopers were called to the location of County Road 600 South and County Road 1000 West in Decatur County at approximately 9:00 am on Tuesday after a Case 435 Quadtrac tractor was stolen from a field in that area that morning. The tractor was connected to two farm implements at the time of the theft and those implements were also stolen.On Wednesday, September 18, after receiving a tip from the public, troopers located the tractor on County Road 420 West near Downeyville in rural Decatur County. The two farm implements were located on Thursday, September 19, near Zenas in rural Jennings County with the assistance of an Indiana State Police helicopter.The Indiana State Police continues to investigate the theft and is asking the public’s help in locating the person or persons responsible for the theft. Due to the size of the tractor, investigators believe the suspect may have had prior experience in operating similar equipment.Anyone with information about the theft is urged to call Master Trooper Rob Ewing, Indiana State Police-Versailles Post at (812)689-5000.
On this day 45 years ago, FC Zeljeznicar achieved the victory against FC Partizan in Belgrade with the score 4: 0 and thus won the title of champion of Yugoslavia, as announced by FKZeljeznicar.ba.At the end of the 1960’s, Milan Ribar became the coach, and he was one of the most successful coaches in the rich history of greats from Grbavica.Blue ones usually played in the following composition: Janjuš, Kojović, Bećirspahić, Bratić, Katalinski, Hadžiabdić, Jelušić, Janković, Bukal, Sprečo and Deraković.“With extraordinary cheering of Zeljo’s fans, on that day, June 11, 1972, Zeljo won against Partizan’s machinery and celebrated with the score 4: 0! Zeljo was superior throughout the entire match, and it was clear that Zeljo is the new champion of Yugoslavia, and that it cannot lose this match.From Sarajevo reported that Crvena Zvezda won against Sarajevo at Kosevo Stadium, but that meant nothing. For the first time in the history, Zeljo was the new champion. And that was all that mattered and that was remembered forever.After the game and chaos at the stadium, great shouting and songs, with the applause of both Zeljo’s and Partizan’s fans, the celebration went on the streets of Belgrade.Zeljo’s fans stopped the traffic on Terazije. They waved their flags and shouted: “Champions, champions!” while the citizens of Belgrade watched them with sympathy and congratulated on their victory.(Source: nap.ba)