Harvard’s 2010 annual report of the Corporation Committee on Shareholder Responsibility (CCSR), a subcommittee of the President and Fellows, is now available upon request from the Office for the Committees on Shareholder Responsibility. To obtain a copy, email [email protected] or call the office at 617.495.0985.The report provides a detailed description of the CCSR’s actions on shareholder proposals raising issues of social responsibility that came to vote during the 2010 spring proxy voting season (the period between March and June when most publicly traded corporations hold annual meetings). The CCSR receives advice from the Advisory Committee on Shareholder Responsibility, a 12-member committee made up of Harvard faculty, students, and alumni.
Harvard Stem Cell Institute (HSCI) researchers have identified in the most aggressive forms of cancer a gene known to regulate embryonic stem cell self-renewal, beginning a creative search for a drug that can block its activity.The gene, SALL4, gives stem cells their ability to continue dividing as stem cells rather than becoming mature cells. Typically, cells only express SALL4 during embryonic development, but the gene is re-expressed in nearly all cases of acute myeloid leukemia and 10 to 30 percent of liver, lung, gastric, ovarian, endometrial, and breast cancers, strongly suggesting it plays a role in tumor formation.In work published in the New England Journal of Medicine, two HSCI-affiliated labs — one in Singapore and the other in Boston — show that knocking out the SALL4 gene in mouse liver tumors, or interfering with the activity of its protein product with a small inhibitor, treats the cancer.“Our paper is about liver cancer, but it is likely true about lung cancer, breast cancer, ovarian cancer, many, many cancers,” said HSCI Blood Diseases Program leader Daniel Tenen, who also heads a laboratory at the Cancer Science Institute of Singapore (CSI Singapore). “SALL4 is a marker, so if we had a small molecule drug blocking SALL4 function, we could also predict which patients would be responsive.”Studying the therapeutic potential of a transcription factor is unusual in the field of cancer research. Transcription factors are typically avoided because of the difficulty of developing drugs that safely interfere with genetic targets. Most cancer researchers focus their attention on kinases.The HSCI researchers’ inquiry into the basic biology of the SALL4 gene, however, revealed another way to interfere with its activity in cancer cells. The gene’s protein product is responsible for turning off a tumor-suppressor gene, causing the cell to divide uncontrollably. Using this knowledge, the researchers demonstrated that targeting the SALL4 protein with druglike molecules could halt tumor growth. “The pharmaceutical companies decided that if it is not a kinase and it is not a cell surface molecule, then it is ‘undruggable,’ ” Tenen said. “To me, if you say anything is ‘undoable,’ you are limiting yourself as a biomedical scientist.”Earlier this year, Tenen’s co-author, HSCI-affiliated faculty member Li Chai, a Harvard Medical School assistant professor of pathology at Brigham and Women’s Hospital, published a paper in the journal Blood, reporting that a SALL4 inhibitor has similar treatment potential in leukemia cells.Chai took blood samples from patients with acute myeloid leukemia, treated the leukemic cells with the inhibitor that interferes with SALL4 protein activity, and then transplanted the blood into mice. The result was a gradual regression of the same cancer in mice.“I am excited about being on the front line of this new drug development,” Chai said. “As a physician-scientist, if I can find a new class of drug that has very low toxicity to normal tissues, my patients can have a better quality of life.”Chai and Tenen are now working with HSCI Executive Committee member Lee Rubin, the Harvard Institute of Chemistry and Cell Biology, and James Bradner of Dana-Farber Cancer Institute, another HSCI-affiliated faculty member, to overcome the technical challenges of drug development and demonstrate the potential of SALL4 interference to treat other forms of cancer.“I think as academics, we seek to engage drug companies because they can do these types of things better than we can,” Tenen said. “But, also as an academic, I want to go after the important biologic targets that are not being sought after by the typical drug company — because if we do not, who will?”The basic research that explored the biology of SALL4 was financed by a 2007 seed grant from HSCI, with more recent funding provided by a Singapore Translational Research Award from the Singapore National Medical Research Council, and grants from the Singapore Ministry of Education and National Research Foundation, and the National Institutes of Health. Kol Jia Yong, Chong Gao, and Henry Yang, among others, contributed to this work.
Share:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to email this to a friend (Opens in new window) WNY News Now File Image.DUNKIRK — The National Night Out event that was planned for September 1 in Dunkirk has been postponed.The decision to postpone the event came after a discussion with the Night Out Committee.It follows a recent cluster of cases found to be associated with the Fieldbrook Foods facility.“This has been a very unique year for all of us with the COVID-19 pandemic,” Dunkirk Police leaders said. There’s no new date scheduled yet, but police say the National Night Out will be rescheduled “once the situation settles down.”
FacebookTwitterLinkedInEmailPrint分享Megan Darby for Climate Change News:The Swedish government is expected to decide this week whether to allow the sale of some of Europe’s most polluting assets. At issue are state-owned Vattenfall’s brown coal mines and plants in Germany, which it wants to offload to Czech firm EPH.Olivia Linander of 350.org urged the ruling parties to “show they take the Paris Agreement seriously” by blocking the transaction.An opinion poll commissioned by Greenpeace, WWF and Swedish Society for Nature Conservation suggests the public is inclined to agree. Nearly half (49%) oppose the sale, compared to 27% in favour.The figures are similar among voters for the Social Democrats, whose minister Mikael Damberg is responsible for the decision: 49% against, 32% for.Vattenfall expects to lose US$2.7-3.3 billion in the transaction, yet argues it is cheaper than holding onto the loss-making business.Shedding the five opencast mines and four power stations will shrink the firm’s carbon footprint by two thirds – seen as desirable for its reputation and bankability.Gerard Wynn, analyst with the Institute for Energy Economics & Financial Analysis, questioned whether it would really be more expensive for Vattenfall to decommission the mines.“If it is about brand, it is not great if you are potentially going to create a big mess in Eastern Germany,” he said. “Which is more important, bankers or your voters?”Sweden faces climate test as voters oppose brown coal sale Resistance in Sweden to Selling, Rather Than Closing, Lignite Mines and Plants in Eastern Germany
The Hispanic market is the largest, fastest-growing segment in this country, but that’s only one reason U.S. credit unions are working hard to learn more about this demographic.Smart credit union executives understand the Hispanic population is very young compared to other U.S. ethnic groups. This presents an opportunity to lower the average age of membership by bringing Hispanics into the fold. Hispanics are also disproportionately underserved, and credit union leaders view helping Hispanics navigate the U.S. financial system as an important part of the overall credit union mission. Lastly, the face of the American consumer is changing, and growing membership means adapting to consumers, rather than forcing them to adapt to the credit union.Seeing the benefit of serving the Hispanic population is one thing. Truly understanding what it takes to do so is another. To gain that understanding, credit unions must begin by examining their current outreach and potential for growth.One way credit unions have pursued this is through strategic planning designed specifically to meet a Hispanic membership growth objective. The most effective plans not only include a roadmap; they also supply a solid benchmark so that credit unions can effectively measure their success and prove the return on their investment.The first step to drafting a good strategic plan is uncovering a credit union’s readiness to reach a new market. Or for those credit unions that have already begun, understanding staff’s readiness to take their efforts to the next level.For its part, the roadmap portion of the strategic plan outlines how a credit union can implement tactics in the proper sequence. This allows the team leading the effort to achieve results much faster and much more cost-effectively than they may without a charted course.A few key questions a credit union should ask and answer as they build out their strategic plan include:Is the credit union well positioned to target and serve the Hispanic market? How many Hispanic members is the credit union currently serving? How many Hispanic members could the credit union serve and what is the income potential? We refer to three stages in the quest to become a successful Hispanic-community credit union: Discovery, Emerging and Best Practice.Credit unions in the Discovery phase are considering Hispanic outreach but have not yet pulled the trigger on any tactical portions of a strategic plan. In fact, most do not yet have a fully formulated plan. They want to learn more; leaders just don’t quite know where to start.In the Emerging phase, credit union staff have recognized the benefits and importance of serving the Hispanic community. They have laid the foundation and taken steps to adapt their products and services to Hispanic members (rather than waiting for the Hispanic members to adapt to them).Best Practices credit unions have successfully served the market for years. They are preferred by Hispanics in their area, have strong financial educational programs and maintain an innovative growth culture.Hispanic growth plans represent an indispensable investment in the future. Yet having a plan on its own will not generate the kind of success a credit union needs. Readiness to executive must be achieved first. Only then can the integration of a Hispanic growth strategy with the credit union’s overall strategic future create sustainable success.To learn more, read the full white paper; “Asking the Right Questions.” 90SHARESShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblr,Miriam De Dios Woodward Miriam De Dios Woodward is the CEO of PolicyWorks, LLC. She also serves as Senior Vice President of AMC, the holding company of the Iowa Credit Union League and parent … Web: https://www.policyworksllc.com Details
13SHARESShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblr,Callie Cady Callie Cady is the Communications & Marketing Manager at Lanvera, a world-class provider of end-to-end outsourcing solutions for transactional documents. At Lanvera, cutting edge technology solutions are coupled with industry … Web: www.lanvera.com Details Today’s credit unions are under pressure to innovate faster with fewer resources and greater flexibility than ever before. Many credit unions understand that these expectations, coupled with growing demands on communications, reveal the importance of tapping into the expertise of a tenured member communications partner.According to Deloitte, 59% of businesses outsource critical services in order to cut costs, and 57% outsource because it enables them to focus on core business functions. Vendor partnerships are vital to your credit union’s growth and success, allowing you to focus on and improve core business functions and utilize dedicated resources to strategically improve processes that affect member retention. However, having too many vendors can backfire.There are multiple member communications options on the market, and most of them claim they are the best solution for your needs. This is where credit unions fall into the trap of managing multiple vendors for document composition, digital delivery/storage and print and mail. While it may seem like a good idea to leverage the “best” vendors in each of the aforementioned categories, this approach can leave you with errors, extra unforeseen costs, unnecessary time spent on managing multiple vendors, and damaged member relationships.When deciding on a single or multi-vendor approach to your member communications, complexity of integration, product update challenges, the potential for downtime, and change management lag time are all legitimate concerns.Complexity of IntegrationEven though we are in the era of software compatibility, there are many systems that were not built using common underlying software architectures. With multiple vendors comes the need for multiple system integrations, and integrating all vendor solutions into a single cohesive system is challenging and expensive. Without integration, you run the risk of duplicate work and lag time due to communicating with more than one point of contact. Alternatively, a single vendor solution will save time and headaches by integrating one comprehensive solution into your credit union’s current system.Product Update ChallengesWith a rapidly changing technology landscape, it’s safe to assume that the savvier member communications vendors will regularly release product updates. With a multi-vendor approach, these updates are aggregated and compound on top of each other and could cause integration interruptions or breakage. A single vendor solution reduces the risk of integration interruptions when updates are released to your credit union. Potential for DowntimeThe more vendors involved, the more potential for downtime. Each vendor increases this threat with every piece of equipment, hardware, software, and network, especially with interoperability challenges. With a consolidated, single-vendor solution, one vendor is responsible for the entirety of your member communications and is more likely to perform reliably.Change Management Lag TimeWorking with multiple vendors creates challenges regarding change management. To make a change, you may have to communicate with multiple points of contact and wait for each of those vendors to make the appropriate changes. This could take much longer than a single-vendor solution, resulting in headaches and potentially damaged member relationships.Wrapping it upWhile a multi-vendor approach may seem like a good idea, it can cause you unanticipated problems that result in a hard hit to your bottom line. A single-vendor member communications solution can help you streamline member communications and strategically aid in your credit union’s efforts to satisfy member expectations.
1:56 Former England captain Michael Atherton says Ben Stokes’ return to England’s T20 squad for next month’s tour of South Africa is a ‘huge bonus’ – Advertisement – “I’m a huge fan of his, I think he’s a fantastic player,” Buttler told reporters. “I think he’s got an excellent cricket brain, I like the way he looks at the game and the way he takes it on.“He’s probably one of my favourite players in the world at the moment. Having played against him, he’s incredibly difficult to keep quiet with the bat, I enjoy his wicketkeeping style as well, he’s a fantastic wicketkeeper.“He’s a brilliant player and he’ll be a real danger man for South Africa on this trip.”
Thirty-seven percent of the survey participants were entrepreneurs, 32 percent were employees, 13 percent informal workers and the remaining 18 percent were public servants, including soldiers and police officers.Read also: Greater Jakartans show low awareness of physical distancing measures despite PSBB: SurveyTransportation and parking management head Khairul Rizal of the Bandung Transportation Agency, who was in charge of the PSBB Survey, said that the survey was a randomized roadside interview. Random motorists were asked to participate in the survey as well as answer written questions from the Bandung Planning, Research and Development Agency.“Based on the survey results, 75 percent of the respondents spend more than six hours on average outside their homes every day, while the remaining respondents stay outdoors for two hours or less,” Rizal said in a statement on Tuesday.The PSBB in Bandung ended on Tuesday. Mayor Oded M. Danial has decided not to apply for an extension and instead wait for the end of the province-wide PSBB on May 20. On Tuesday, the city of Bandung recorded 235 confirmed cases with 35 deaths. West Java is the second-hardest hit province in the country after Jakarta, with at least 1,300 confirmed cases and 87 deaths as of Tuesday. (vny)Topics : Many people are venturing out of their homes in Bandung, West Java, despite the large-scale social restrictions (PSBB) because they fear losing their jobs more than they fear contracting COVID-19, a recent city survey has found.The survey, which canvassed 310 passersby at eight different locations in the city, found that 62 percent of respondents had ventured out of their homes because they were afraid of losing their jobs. Meanwhile, 26 percent of respondents said they had come into the city because they were worried that their incomes would fall if they stayed at home.Only 10 percent of respondents said they were afraid of contracting the coronavirus, while a mere 2 percent said they were afraid of dying of COVID-19.
Metro Sport ReporterTuesday 19 Mar 2019 4:23 pmShare this article via facebookShare this article via twitterShare this article via messengerShare this with Share this article via emailShare this article via flipboardCopy link104Shares Rio Ferdinand tells Ole Gunnar Solskjaer to drop struggling Read More Coming Next About Connatix V67539 Full Screen by Metro Read More Video Settings / More: Arsenal FCArsenal flop Denis Suarez delivers verdict on Thomas Partey and Lucas Torreira movesThomas Partey debut? Ian Wright picks his Arsenal starting XI vs Manchester CityArsene Wenger explains why Mikel Arteta is ‘lucky’ to be managing Arsenal Visit Advertiser website GO TO PAGE 1 min. story Advertisement Manchester United captain Harry Maguire SPONSORED Top articles PLAY Denis Suarez is still waiting to make his first Arsenal start since his move from Barcelona (Picture: Getty)Denis Suarez appears to have hit back at reports Unai Emery will send him back to Barcelona at the end of the season.The Spaniard joined Arsenal on loan until the end of the season in January but has struggled to make an impression and is still waiting to make his first start.Suarez has made just six substitute appearances and has struggled to oust the likes of Henrikh Mkhitaryan and Alex Iwobi, having been recruited to give his manager another option in wide areas.The Sun claimed on Monday that Emery holds reservations over the midfielder’s ability to withstand the physical demands of English football and will not take up the option to make the deal a permanent one for £18million come the summer.AdvertisementAdvertisementADVERTISEMENT Read More Skip Unai Emery tried to sign Christopher Nkunku of Paris Saint Germain in January (Picture: Getty)He said: ‘I think Suarez is improving with his adaptation every day. Then his quality can give us a lot.‘I think he is not OK today to play 90 minutes because he needs rhythm. But one positive is he can start [against Bournemouth] knowing that, or he can stay on the bench and then help us.’More: Arsenal FCArsenal flop Denis Suarez delivers verdict on Thomas Partey and Lucas Torreira movesThomas Partey debut? Ian Wright picks his Arsenal starting XI vs Manchester CityArsene Wenger explains why Mikel Arteta is ‘lucky’ to be managing Arsenal Read More Arsenal star Denis Suarez reacts to speculation Unai Emery will send him back to Barcelona Skip Ad Comment Arsenal can sign Denis Saurez on a permanent basis for £18million (Picture: Instagram)Suarez, however, took to Instagram on Wednesday, posting a picture of himself taken during first team training with the caption ‘let them keep talking’.Emery is said to be already considering Suarez alternatives, incuding the likes of PSG’s Christopher Nkunku and Rennes’ Ismaila Sarr.Last month, the Arsenal manager insisted he believed the player he coached during their time together at Sevilla would be capable of making an impact in north London. 1/1 Advertisement Read More
The €300m Dutch pension fund for the travel sector has said it was looking for a merger with a larger industry-wide scheme or a switch to defined contribution (DC) arrangements.Reiswerk Pensioenen made clear that continuing independently was not an option because of its funding position and its predominantly young membership. “The long duration as a consequence of our young population requires taking more investment risk,” said Frank Radstake, the scheme’s employer chairman. ”But the financial assessment framework (FTK) doesn’t allow us to do so because of our funding shortfall.”The pension fund was therefore “stuck in the FTK trap.” The small sector scheme has been in trouble since the introduction of a new and lower ultimate forward rate (UFR) in 2015, part of the discount mechanism for liabilities.Despite a defensive investment policy, including a 90% interest hedge, the scheme’s funding level has since plummeted from 125% in 2014 to 99.5%.In its annual report, Reiswerk Pensioenen said it was unable to hedge against the impact of the new UFR, which had caused a steep rise of its long-term liabilities.Radstake said the UFR was expected to drop further and that the current asset mix would not solve the pension fund’s financial problems.He indicated that the scheme’s small size – it has 9,000 active members – was another reason why it wasn’t deemed future-proof.Joining another sector scheme or switching to DC would both give Reiswerk the option to increase the risk profile of its investments.A merger would bring the added benefit of scale, but would also mean an instant rights cut for the scheme’s members.“However, in the long term the results will improve,” said Radstake.Based on its current position, the pension fund was headed for a rights discount in 2021 anyway, he noted.The social partners in the travel industry said they wanted to make a decision about the scheme’s future next summer.