Sept 7, 2006 (CIDRAP News) – In a human trial in China, a whole-virus H5N1 avian influenza vaccine generated an immune response with a relatively low dose of antigen, suggesting that it could be used to immunize more people than may be possible with some other vaccines under development.The study, published online today in The Lancet, showed an adequate immune response in 78% of volunteers after two 10-microgram (mcg) doses of the vaccine plus an aluminum hydroxide (alum) adjuvant. That exceeds the European Union’s requirement of an acceptable response (a hemagglutinin-inhibition titer of 40 or more) in 70% of volunteers.The vaccine is made by Sinovac Biotech in Beijing, China, from an inactivated strain of H5N1 known as Vietnam/1194/2004. The report says that Sinovac was involved in designing and monitoring the study but played no role in collecting the data or writing the report.The randomized, placebo-controlled, double-blind study involved 120 adults (aged 18 to 60). They were divided into five groups of 24, with each group receiving either a placebo or 1.25, 2.5, 5, or 10 mcg of the vaccine.Each volunteer received the vaccine on the first day of the study and 28 days later. Serum samples were assessed for evidence of an immune response on days 0, 14, 28, 42, and 56.An antibody response was seen after the first injection at all dose levels. The highest response (78% seropositivity) was seen in the 10-mcg group after two doses.The investigators reported that all four doses were well tolerated, even though whole-virion vaccines are generally thought to cause more reactions than split-virion vaccines. No serious reactions were reported, and most local and systemic reactions were mild and brief. Three people dropped out of the study, and one person was excluded from the final analysis.The authors concluded that the dose required to reach an acceptable immune response was much lower than for vaccines reported in previous studies. Two reports published earlier this year described trials of a split-virus H5N1 vaccine developed by Sanofi Pasteur. The reports said two 90-mcg doses of nonadjuvanted vaccine or two 30-mcg doses of adjuvanted vaccine were required to produce the desired immune response.(In July, GlaxoSmithKline reported a good immune response in 80% of volunteers who received a dose of only 3.8 mcg of the company’s adjuvanted H5N1 vaccine. However, a full report of those findings has not yet been published.)”The manufacturing capacity for an H5N1 vaccine would increase if a whole-virion vaccine is used, because 20% to 30% of vaccine antigen is expected to be lost during the disruption process in the preparation of split-virion vaccines, according to our experience with seasonal influenza vaccine,” the Chinese researchers write.In an accompanying commentary, Iain Stephenson, MD, of the Infectious Diseases Unit at Leicester Royal Infirmary in Leicester, England, writes that the findings point up of “a potential dose-sparing approach that could be crucial for a global supply of pandemic vaccine.”He says that trial results for split-virion H5N1 vaccines have been disappointing, because within current manufacturing constraints, the two such vaccines under development would yield only enough to vaccinate 75 million to 225 million people.Though whole-virion vaccines generally produce a better immune response than split or subunit vaccines, development of whole-virion H5N1 vaccines has been delayed, Stephenson writes. He says it is difficult for manufacturers that produce split seasonal vaccines to switch production approaches and processing methods.Stephenson cautions that whole-virion vaccines have been associated with febrile reactions in children and emphasizes that careful investigation is needed before such vaccines can be widely used.It remains to be seen whether whole-virion vaccines can induce the broad cross-reactive response that would be needed to treat a variety of H5N1 viruses, Stephenson writes.Lin J, Zhang J, Dong X, et al. Safety and immunogenicity of an inactivated adjuvanted whole-virion influenza A (H5N1) vaccine: a phase 1 randomised controlled trial. Lancet 2006 (early online publication, Sep 7) [Abstract (registration required)]Stephenson I. H5N1 vaccines: how prepared are we for a pandemic? (Commentary). Lancet 2006 (early online publication, Sep 7)See also:May 12 CIDRAP News story “Sanofi reports results for H5N1 vaccine with adjuvant”Jul 26 CIDRAP News story “Glaxo says its H5N1 vaccine works at low dose”
West Florida drops second straight game to a GSC West Team Share Nov. 24, 2007 Box Score RUSSELLVILLE, Ark. – The West Florida women traveled to Arkansas for two games this weekend in a holiday tournament, and spent both games trying to catch up the entire game. After making a great comeback against Arkansas Tech on Friday night to force overtime, the Argonauts nearly did the same in Saturday’s loss to Ouachita Baptist. Down as much as 16 points early in the second half, West Florida battled back to get within two points with 59 seconds to play, but Ouachita Baptist hit five free throws to seal the 71-64 win.West Florida started the contest by hitting their first three baskets, but then went 14 straight possessions without a basket, and fell behind 22-7. For the rest of the night they played catch up. Amy Drake hit a three pointer to start the scoring, followed by a jumper by Tara Russ, and then a layup by Drake put the Argos up 7-5. Then the major slump, in which Ouachita Baptist scored 17 straight points to go up 22-7. The Argos closed the gap to 32-28 on a three pointer from Chelsea Patterson with 1:16 left in the first half. However, the Lady Tigers scored the final four points of the half to lead 36-28 at intermission.Ouachita Baptist scored the first four points of the second half to push the lead to 40-28. Midway thru the second half, the Argos scored seven straight points and after a three pointer by Laura Davis, they trailed only 45-41. Ouachita Baptist would extend the lead again to 13 points, 60-47 with 6:14 remaining, on the strength of Gabby Coleman. Coleman would score 26 points to lead everyone in the game.The Argonauts would fight back again, and scored 10 straight points to close to within two points on a driving layup by Davis, and two three pointers from Patterson. With the score 66-64 with one minute to play, the Argonauts ran out of gas, and the Tigers hit five Free Throws to finish the game.The Argonauts fall to 2-3 on the season, while Ouachita Baptist improved to 1-3 on the season. Russ had a strong game with 17 rebounds, two blocks, and two steals, to go along with her 12 points. Patterson led West Florida with 17 points, while Drake added 13 points and nine assists. Dominique Boykins added eight points and six rebounds, as the Argonauts out-rebounded the Tigers 40-36. Meanwhile, Renee Polk came off the bench to score seven points to help the Argonauts battle back in the second half.West Florida returns home to play Albany State Tuesday night at 5:30 pm, as part of a doubleheader with the men’s team. The men’s team takes on William Carey College at 7:30 pm. Both games take place in the UWF Fieldhouse. Print Friendly Version
BROWARD COUNTY – As part of its ongoing recovery and relief efforts to support residents displaced by Hurricane Dorian, Broward County Public Schools (BCPS) has opened a Welcome Center to help students and families arriving from the Bahamas.The BCPS Welcome Center is located in the Lauderdale Manors Early Learning & Family Resource Center, at 1400 NW 14th Court in Fort Lauderdale, 754-323-1595. The Welcome Center provides families with support for student registration into District schools, and once registered, connects families to school social workers, who provide school supplies, uniforms and clothes, food, and information on local resources. In addition, the Welcome Center offers access to a variety of health services, in partnership with the Florida Department of Health in Broward.The Welcome Center is open during the following times:Mondays and Wednesdays 8 a.m. – 4 p.m.Tuesdays and Thursdays 10 a.m. – 6 p.m.Fridays 9 a.m. – 5 p.m.When the Welcome Center is closed, families should contact the Family & Community Engagement Office at 754-321-1599 for assistance. As the need for support increases, the District will offer additional hours of operation.The District continues to collaborate with the Broward Education Foundation, United Way of Broward County and BrightStar Credit Union to collect and deliver donations and resources to assist with Hurricane Dorian recovery efforts in the Bahamas. For more information on the District’s Hurricane Dorian relief and recovery efforts, visit browardschools.com/hurricanerelief.