Sept 7, 2006 (CIDRAP News) – In a human trial in China, a whole-virus H5N1 avian influenza vaccine generated an immune response with a relatively low dose of antigen, suggesting that it could be used to immunize more people than may be possible with some other vaccines under development.The study, published online today in The Lancet, showed an adequate immune response in 78% of volunteers after two 10-microgram (mcg) doses of the vaccine plus an aluminum hydroxide (alum) adjuvant. That exceeds the European Union’s requirement of an acceptable response (a hemagglutinin-inhibition titer of 40 or more) in 70% of volunteers.The vaccine is made by Sinovac Biotech in Beijing, China, from an inactivated strain of H5N1 known as Vietnam/1194/2004. The report says that Sinovac was involved in designing and monitoring the study but played no role in collecting the data or writing the report.The randomized, placebo-controlled, double-blind study involved 120 adults (aged 18 to 60). They were divided into five groups of 24, with each group receiving either a placebo or 1.25, 2.5, 5, or 10 mcg of the vaccine.Each volunteer received the vaccine on the first day of the study and 28 days later. Serum samples were assessed for evidence of an immune response on days 0, 14, 28, 42, and 56.An antibody response was seen after the first injection at all dose levels. The highest response (78% seropositivity) was seen in the 10-mcg group after two doses.The investigators reported that all four doses were well tolerated, even though whole-virion vaccines are generally thought to cause more reactions than split-virion vaccines. No serious reactions were reported, and most local and systemic reactions were mild and brief. Three people dropped out of the study, and one person was excluded from the final analysis.The authors concluded that the dose required to reach an acceptable immune response was much lower than for vaccines reported in previous studies. Two reports published earlier this year described trials of a split-virus H5N1 vaccine developed by Sanofi Pasteur. The reports said two 90-mcg doses of nonadjuvanted vaccine or two 30-mcg doses of adjuvanted vaccine were required to produce the desired immune response.(In July, GlaxoSmithKline reported a good immune response in 80% of volunteers who received a dose of only 3.8 mcg of the company’s adjuvanted H5N1 vaccine. However, a full report of those findings has not yet been published.)”The manufacturing capacity for an H5N1 vaccine would increase if a whole-virion vaccine is used, because 20% to 30% of vaccine antigen is expected to be lost during the disruption process in the preparation of split-virion vaccines, according to our experience with seasonal influenza vaccine,” the Chinese researchers write.In an accompanying commentary, Iain Stephenson, MD, of the Infectious Diseases Unit at Leicester Royal Infirmary in Leicester, England, writes that the findings point up of “a potential dose-sparing approach that could be crucial for a global supply of pandemic vaccine.”He says that trial results for split-virion H5N1 vaccines have been disappointing, because within current manufacturing constraints, the two such vaccines under development would yield only enough to vaccinate 75 million to 225 million people.Though whole-virion vaccines generally produce a better immune response than split or subunit vaccines, development of whole-virion H5N1 vaccines has been delayed, Stephenson writes. He says it is difficult for manufacturers that produce split seasonal vaccines to switch production approaches and processing methods.Stephenson cautions that whole-virion vaccines have been associated with febrile reactions in children and emphasizes that careful investigation is needed before such vaccines can be widely used.It remains to be seen whether whole-virion vaccines can induce the broad cross-reactive response that would be needed to treat a variety of H5N1 viruses, Stephenson writes.Lin J, Zhang J, Dong X, et al. Safety and immunogenicity of an inactivated adjuvanted whole-virion influenza A (H5N1) vaccine: a phase 1 randomised controlled trial. Lancet 2006 (early online publication, Sep 7) [Abstract (registration required)]Stephenson I. H5N1 vaccines: how prepared are we for a pandemic? (Commentary). Lancet 2006 (early online publication, Sep 7)See also:May 12 CIDRAP News story “Sanofi reports results for H5N1 vaccine with adjuvant”Jul 26 CIDRAP News story “Glaxo says its H5N1 vaccine works at low dose”
Sharing is caring! Passport of the Commonwealth of Dominica. Image via: thedomnican.netThe Government of Dominica wishes to make the following response to statements in the media that Dawood Ibrahim (or IbrahimDawood) an allegedly notorious Pakistani terrorist is the holder of a Dominica passport.The information available to the Government of the Commonwealth of Dominica is that the source of this allegation is Thompson Fontaine. The person called or described as Jeremy Sinclair is unknown. The Government has not granted, and denies that it granted, economic citizenship ora passport to Mr. Ibrahim. More importantly, the security and due process measures in place would make it impossible for a notorious criminal and wanted terrorist to be granted economic citizenship or passport.The allegation istotally false.In view of the clear measures in place, and the measures taken to protect the security of the Commonwealth and other sovereign states, there is strong and compelling reason to believe that this allegation is part of the on going conspiracy by some to destroy the reputation of the country for their own partisan gain and purposes by any means necessary. As a result, the Government demands that Dr Fontaine and others who are peddling this fabrication to the region and world produce immediately the evidence to substantiate the allegation. The Government of Dominica intends to conduct inquiries to get to the bottom of this scandalous attack on the integrity of the Nation and seek legal advice as to whether any criminal or civil proceedings can be instituted against Dr. Thompson Fontaine and others involved in this attack against Dominica.Press ReleaseFinancial Services Unit, Government of Dominica Share Share Tweet LocalNews Pakistani terrorist is not a holder of Dominica passport – says officials by: – November 10, 2011 25 Views no discussions Share
The goalkeeper of BH national football team and English Stoke City, Asmir Begovic, put yesterday his pink gloves at the auction that lasts 48 hours, writes BH news agency Patria.These gloves are made especially for our goalkeeper at the occasion of the Mother’s Day (15th March), and he wore them at the match against West Bromwich Albion on Saturday.You can send your offers to the mail email@example.com and the most generous offer wins. Auction starts with 100 pounds.All funds collected from the auction will be divided between the foundations Asmir Begovic and Gingerbread in England.Foundation Asmir Begovic is established two years ago, and the main purpose is help to children in Great Britain and Bosnia and Herzegovina.(Source: nap.ba)
McNamara was close to finishing that project when he was murdered — one of five victims in the June 2018 mass shooting at the offices of the Capital Gazette newspaper in Annapolis, Md.“I guess for the two months after he died I couldn’t bring myself to go into his den,” Chamblee told Sporting News. “I kept the door closed. I shuddered when I walked past it. He should have been in there working on this book. He was every night when we were home and he wasn’t at a game.“But after about two months I opened the door and tried to remember what it was like when he was there. And the boxes of the files were so conspicuous to see in the middle of the floor — just boxes and boxes of microfiche that he had printed out and telephone numbers he had called. And there was a list of people that he wanted to call back pasted above his desk.“And I decided to take a look to see how far along he had gotten.”McNamara was a staff writer at the Annapolis paper at the time of his death, but his enthusiasm for sports was addressed most nights by wrapping himself in the history of D.C.-area high school basketball. The region long has been extraordinarily rich in basketball talent: Dave Bing, Austin Carr, Adrian Dantley, Victor Oladipo, Danny Ferry, Adrian Branch, Sidney Lowe, Sherman Douglas and Len Bias all were products of its high school teams. There is a listing of all-area teams near the back of “The Capital of Basketball,” starting in the 1920s and carrying forward to 2000, that is loaded with eventual All-Americans, NBA All-Stars and Naismith Hall of Famers.He expressed in the introduction to this book how, already an enormous fan of the NBA and colleges, he came to fall in love with the high school game by attending with his father a matchup of Archbishop Carroll and the private school he had entered, St. John’s. He was “hooked” for life.“In terms of value for your entertainment dollar,” McNamara wrote, “I still believe you can’t beat a good high school basketball game.”McNamara wrote a couple of books about the athletic program at Maryland, his alma mater, one each about football and basketball. Like many writers, he had in his mind a project or two he wanted to address when he found the time. He wanted to write about the history of D.C. high school hoops, but when he learned about the death of legendary coach Bob Dwyer, who had led Archbishop Carroll to 55 consecutive victories in the 1950s, McNamara told his wife he’d missed his chance. She knew better.Chamblee reminded McNamara that Hall-of-Famer Morgan Wootten of DeMatha Catholic and Joe Gallagher of St. John’s were among the elite coaches still around then, with lifetimes of stories to tell. She urged McNamara to contact them and collect their memories and, when the time came, to put it all on paper.“He had been working on it, and I had helped him back up those files, so I knew where they were,” Chamblee said. “He didn’t like me to read his works in progress, but I had put them on a thumb drive and on the cloud and then a few places, so that if we lost one we’d have other backups. I decided to search them out and download them and open them up.“He was so close to finishing. I thought I had to be able to do this for him and finish it.”With help from D.C. area sportswriter David Elfin, who had collaborated with McNamara on “Cole Classics! Maryland Basketball’s Leading Men and Moments,” Chamblee was able to complete the book in time for it to be published as the 2019-20 basketball season commenced.The idea of the book was to cover the 20th century, ending with Wootten’s induction into the Naismith Memorial Hall of Fame in 2000. He’d covered all but the final two years of the 1990s, and Chamblee said Elfin was an enormous help in addressing those seasons and proofreading the entire work. The opening chapter covering 1900-1950 was not yet done, but McNamara had so thoroughly outlined what he had planned, Chamblee said, “Really, all I had to do was turn his outline into complete sentences and write it the way he would want it to be written.”The completed work is a tribute to McNamara’s encyclopedic knowledge of the basketball scene in the D.C. metro area. It is published by Georgetown University Press. Academic houses often prefer the work they produce to have been peer-reviewed before publication. But no one could find a “peer” in this arena; McNamara was the authority.Chamblee is a former newspaper reporter who became an attorney and now works as senior regulatory counsel for the Food and Drug Administration. She was out of work, temporarily, during the government shutdown earlier this year, but that provided her time to finish her husband’s book project.“If the government hadn’t shut down for those six weeks, I don’t think we’d be talking about this book today,” she said. “I couldn’t take on another job — that’s not allowed — so I just worked 12-hour days finishing the book.”Some of what was required was identifying the subjects of photographs; McNamara didn’t always write them down because he’d have known them at a glance. Chamblee got some help from other writers and credited Wootten and Maryland basketball voice Johnny Holliday for being generous with their time in helping to assure accuracy. Hall of Fame coach Gary Williams, who coached at Maryland from 1989-2011, agreed to write the foreword, explaining he got to know McNamara on a professional level, “and then as a friend.” There is a special feeling for an author when the first copy of a book arrives, usually in the mail or by courier service. So many years of labor can go into such a project, and to hold it all in one’s hands is an extraordinary experience. Few, though, have felt anything like what Chamblee did when “The Capital of Basketball” was delivered to her.“I was so conflicted when I held that book in my hand,” Chamblee said. “Of course, these days you email off the files, so even just hitting the send button on the files felt like I was letting it go. Maybe it feels a little like a parent dropping their child off at college.“And when it came back, part of me wanted to keep it like this was my secret between John and I, and I didn’t want to share it. But certainly, I knew I needed to share it. John wanted people to know these stories, so I have to let it go.” For about two months, the last words John McNamara had to share with his readers — words that represented over a decade’s worth of research, conversation, investigation and, above all, passion — sat untouched in his office.In 2007, he began the project that would become “The Capital of Basketball” at the urging of his wife, Andrea Chamblee. She knew was no one was more qualified to write the history of the incredible high school basketball competition that has flourished for over a century in the Washington D.C. metro area.
1 Leicester have reached an agreement to sign Sevilla midfielder Vicente Iborra, the Spanish club have announced.The 29-year-old Spaniard is now expected to meet Leicester officials to discuss a contract and undergo a medical.Reports have suggested Iborra, who played against the Foxes in the Champions League last season, will cost the English club around £12million.Iborra, who can also operate as a forward, has scored 30 goals in 172 games since joining Sevilla from Levante four years ago.He has won the Europa League three times and he captained the side last season. He has previously been linked with Sunderland and West Ham.A statement from Sevilla read: “Sevilla FC and Leicester City FC have reached an agreement in principle for the transfer of Vicente Iborra.”Once a deal is concluded, Iborra will be allowed to return to Sevilla to bid a public farewell to fans.Leicester have not yet commented on the development. Vicente Iborra is set to swap Sevilla for Leicester