Monkey HIV vaccine ‘effective’, say researchers

first_img 17 Views   no discussions Sharing is caring! Share Tweet HealthLifestyle Monkey HIV vaccine ‘effective’, say researchers by: – May 12, 2011center_img Share Share A new vaccine can protect macaques against the monkey equivalent of HIV and could provide a fresh approach to an HIV vaccine, a study suggests.US researchers say the vaccine offered protection to 13 of 24 rhesus macaques treated in the experiment.In 12 of the monkeys, the vaccine was still effective 12 months later.They claim the work, published in the journal Nature, could “significantly contribute” to the development of an effective HIV/Aids vaccine.The researchers gave 24 healthy rhesus macaques a vaccine containing a genetically modified form of the virus, rhesus cytomegalovirus (CMV).The vaccine was engineered to produce antigens to attack simian immunodeficiency virus (SIV), the monkey equivalent of HIV.It was shown to offer complete control against SIV within 13 of the monkeys, with half the monkeys still protected a year on.The vaccine worked by stimulating the production of a particular type of blood cell, called “effector memory T-cells”, which can remain vigilant in the body long after an infection has abated, providing long-term protection.Lead author Professor Louis J Picker, of the Vaccine and Gene Therapy Institute in Oregon, compares these cells to armed soldiers at the ready.“There are soldiers that are back at the base with their rifles in the shed, and then you have the guys out in the field,” he told the BBC.There was also evidence, he said, that the vaccine all but eradicated traces of SIV in the monkeys, something which he said was “unprecedented” in HIV vaccine research.Safety concernsResearchers in the field welcomed the research, but said safety issues would need to be addressed before similar approaches could be tried in humans.“I’m excited by the science because it really does demonstrate that it may be possible to eradicate the HIV virus by a strong immune response,” said Professor Sir Andrew McMichael of Oxford University.“But at the same time I’m scratching my head how to take this approach into humans.”Professor McMichael said HIV arose from a type of SIV found in chimpanzees, so the animal model used in the study was a good one. The problem, he said, was the potential safety and regulatory issues with introducing CMV into humans, even though many of us already carry the virus.“CMV is not totally benign, it does cause a number of diseases. If you’re giving people something you’re not going to be able to get rid of should it cause problems, then that’s quite a difficult risk to manage.”Professor Robin Shattock of Imperial College, London, agreed safety would be key.“The breakthrough here is in using a viral-delivered vaccine that persists – essentially using an engineered virus to thwart a pathogenic virus. The tricky part will be showing it is safe and effective in humans.”Professor Picker responded by saying such issues would be addressed in forthcoming work, pointing out that early forms of the smallpox vaccine also carried health risks to humans.“On one level 99% of people in sub-Saharan Africa are CMV-positive and half the people in the developed world are, so we know at lot about it and it’s mostly non-pathogenic, except in vulnerable populations like pregnant women,” he said.“We’re fully aware to make it available to humans, then the next step is to make a virus which retains or has an enhanced ability to make effector memory cells, but no longer has the capacity to infect vulnerable parts of the population.”Vaccine failureDeveloping an HIV vaccine has so far proved a deeply challenging task, but there have been some promising results.In 2009, researchers in Thailand published in the Lancet the results of an experimental HIV vaccine, which they said reduced by nearly a third the risk of contracting HIV.Then last year, a study in the New England Journal of Medicine suggested a drug used to treat HIV-positive patients may offer gay and bisexual men some protection against contracting the virus.Trials of the combination drug Truvada among nearly 2,500 men suggested it could reduce the chances of male-to-male HIV infection by 44%.But major breakthroughs remain hard to come by. Indeed, the new Nature study comes as a separate paper in The Lancet Infectious Diseases reports on the failure of an HIV vaccine trial in South Africa.The MRKAd5 HIV-1 vaccine was trialled in a study involving 801 patients, and no evidence was found that the vaccine was effective.However, the report authors concede that the study’s conclusions may have been compromised by a premature end to the trial.BBC Newslast_img read more

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County Woman Leader Roundtable Set For Monday Night

first_imgGREENSBURG – Women leaders in Decatur County are invited to a roundtable meeting hosted by the Indiana Farm Bureau Monday.The purpose of the meeting is to prompt discussion among women that are leaders in the county.Some were notified by mail and others received updates in the monthly county woman leader newsletter.The roundtable will be held at the Decatur County Farm Bureau Office on Washington Street in Greensburg at 9 a.m.last_img

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Chargers Defeat Lions On The Links

first_imgThe North Decatur Chargers defeated The Rushville Lions 202-228 in Boys Varsity Golf action.Courtesy of Chargers Coach David Espinda.last_img

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Buckingham Palace is Having a Makeover

first_imgIt looks like the Royal Family has a huge project on their hands. We look forward to seeing the new Buckingham Palace! Buckingham Palace is updating its water and heating systems as part of its multi-million revamp to become more environmentally friendly. The Royal Family also shared a video on their Twitter account detailing the renovations to take place.Watch: The boilers in Buckingham Palace are over 30 years old and, as part of the Reservicing Programme, are in urgent need of replacement. Find out more about how these boilers are being replaced. pic.twitter.com/vsCZcRffOk— The Royal Family (@RoyalFamily) May 10, 2019 Queen Elizabeth’s residence, Buckingham Palace is currently being renovated. Several pieces from the  East Wing were transferred to other areas in Buckingham Palace in order for the renovations to take place. According to the Palace,  many items will be on display in Brighton’s Royal Pavilion.Photos of the changes that have taken place were posted on The Royal Family’s official Twitter account.Recently, @RCT have removed all objects from #BuckinghamPalace’s East Wing, including over 3,000 works of art.Shown here is the Principal Corridor, home to the Centre Room, which leads onto the historic balcony – used by the Royal Family on national occasions. pic.twitter.com/OdfH4uXcK9— The Royal Family (@RoyalFamily) May 10, 2019last_img read more

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Ellsworth baseball team defeats Belfast, MDI to reach 9-0

first_imgELLSWORTH — The Ellsworth baseball team is within striking distance of first place in the Class B North standings after recent victories over Belfast and Mount Desert Island.Last Thursday, Ellsworth earned a road 3-2 win over Belfast to finish the first half of the regular season with unbeaten record at 8-0. Belfast had responded to Ellsworth runs to start off the first and sixth innings by tying the game both times, but the Lions were unable to do so a third time after freshman Hunter Curtis scored in the top of the seventh.Senior pitcher Matt Burnett struck out nine batters in seven innings against Belfast to improve to 4-0 on the season. Junior Jackson Curtis led the Eagles at the plate with two hits and two RBIs. Tyler Mitchell and Michael Palmer also had base hits.On Monday, Conner Wagstaff led the way for Ellsworth as the Eagles notched an 8-1 home win over No. 5 MDI (5-4). The senior struck out 11 batters in 5 2/3 innings of work before Burnett recorded the game’s final four outs on strikeouts in relief. Burnett and Jackson Curtis had two hits apiece for the Eagles, who had seven as a team.This is placeholder textThis is placeholder textThe wins moved the No. 2 Eagles (9-0) within 5.2 Heal points of top-ranked Hermon (11-0) in the Class B North standings. The Hawks had 64.8 points to Ellsworth’s 59.6 following Monday’s games. The two teams will play one another at 4:30 p.m. next Thursday, May 23, at Hermon High School.Before that, Ellsworth will battle sixth-ranked Brewer (6-2) at 4:30 p.m. Thursday, May 16, in a rematch of last year’s regional championship game. The Eagles will then play at that time on the road against George Stevens Academy (7-1), at home against John Bapst and at Washington Academy on Friday, May 17, Monday, May 20, and next Tuesday, May 21, respectively.last_img read more

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Cricket News India was granted permission to wear Army-style caps: International Cricket Council

first_imgLast month, the BCCI had asked the ICC to “sever ties with countries from which terrorism emanates” following the Pulwama attack in which 40 CRPF jawans were killed. The responsibility of the attack was taken by Pakistan-based terror outfit Jaish-e-Mohammed.Meanwhile, the men-in-yellow have come strong in this series. Having lost the first two games of the five-match series, Aaron Finch-led Australia won the third and fourth ODI to level the series. With this, final ODI between two sides is important for India for two reasons – 1. This will be their last encounter before the forthcoming World Cup. 2. The series is at stake. (With Inputs: PTI) New Delhi : The International Cricket Council (ICC) Monday said India was granted permission to wear camouflage military caps in the third ODI against Australia as a tribute to the country’s armed forces, a gesture which Pakistan has objected to. In the third ODI in Ranchi on March 8, the Indian team sported military caps as a mark of respect to the CRPF personnel who were killed in the Pulwama terror attack and donated its match fee to the National Defence Fund.”The BCCI sought permission from the ICC to wear the caps as part of a fundraising drive and in memory of fallen soldiers who have died, which was granted,” ICC’s General Manager Strategic Communications Claire Furlong said in a statement.The Pakistan Cricket Board had sent a strongly-worded letter to the ICC, calling for action against India for wearing the caps.”They took permission from ICC for some other purpose and used it to do something else, which is not acceptable,” PCB Chairman Ehsan Mani said on Sunday in Karachi. The final ODI between two sides is scheduled to be played on March 13 in Delhi. Indian players had worn the army-style caps in the third ODI. This will be India’s last game before the World Cup.  highlights For all the Latest Sports News News, Cricket News News, Download News Nation Android and iOS Mobile Apps.last_img read more

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HSC campus installs ‘SmartFridges’ to combat food insecurity

first_img“Many USC students and faculty visit our storefront at 23rd and Union, but a [fridge] on campus will provide 24/7 access to our meals,” Polk wrote in a statement to the Daily Trojan. “In our journey, we’ve committed to serving the communities most vulnerable to food insecurity, and that includes college students.” USC’s Health Sciences Campus installed new SmartFridges across facilities in late July to provide faculty, students and guests with healthy and accessible meals to go. The University installed the new technology to alleviate concerns that the 79-acre Lincoln Heights campus is a food desert. “We envision a day where no student has to worry about where their next meal will come from, and eventually, everyone across the country has access to healthy, affordable food,” Polk wrote. “Over at the Soto buildings on the HSC campus, we were looking for alternatives for the people who were in those buildings,” Marschall said. “It’s kind of like a food desert, it’s very barren of food options over there.” According to Everytable CEO Sam Polk, the SmartFridges will bring made-from-scratch meals to more people in an efficient setting.  According to Marschall, the  fridges have received positive responses so far. “We decided to give it a shot and reached out to the folks that had the technology,” said Kris Klinger, the assistant vice president of USC Hospitality. “We are always idea-networking with what is out there and what we can bring to campus.” “The reaction has been good. We had been letting the community know that [the fridges] were coming,” Marschall said. “A lot of people were aware of it and were excited to see what it was and give it a shot.” According to Klinger and Marschall, USC Hospitality initially considered the University Park Campus as a location to implement the smart fridges but decided that the HSC had a more urgent need for the food options. Conversations are currently ongoing to install the machines at University Park. center_img The SmartFridge an innovation created by Everytable, a company dedicated to providing healthy meals in food deserts, is narrower than a vending machine and can be accessed by swiping a credit card on the terminal. Users can open the fridge and examine various dining options. Once the user chooses their meal and closes the door, the fridge will scan its contents to determine the respective price of the item missing. For added convenience, the University also installed microwaves near the fridges to heat meals.  The current menu is a collection of 50 of the top-rated items from Everytable. It includes dishes such as carnitas bowls, Jamaican jerk chicken bowls, spaghetti and meatballs and salads. According to Everytable, the menu is inspired by the culture and flavors of L.A. “Vending in general is starting to go through some really big changes,” Marschall said. “It’s not your old school Coke machine or snack machine, there are going to be a lot more changes providing higher quality food.” According to Gary Marschall, the senior associate director of Retail Operations for USC, the refrigerators will ensure that there are more food options at HSC, which houses the Keck School of Medicine, the School of Pharmacy and three large teaching hospitals.  Polk believes that food insecurity is a growing problem on college campuses that can affect a student’s academic performance.  The Health Sciences Campus partnered with Everytable, a food company that sells healthy meals in food deserts, to put its products in smart fridges. (Photo courtesy of Everytable) Once the fridges have been operating for long enough, Everytable will be able to use its data to gain personalized feedback on how specific items are selling. last_img read more

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Lewis Hamilton on pole for Spanish F1 Grand Prix

first_imgLewis Hamilton’s on pole for this afternoon’s Spanish Formula One Grand Prix.The three-time world champion was fastest in qualifying and also first in both practice sessions in Barcelona.Hamilton’s ahead of Ferrari’s championship leader Sebastian Vettel and Mercedes teammate Valtteri Bottas.last_img

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Wigwe Salutes Access Bank Games’ Participants

first_imgHe added that the Games will be an annual event with more games to be introduced in the next edition.“We just devote ourselves to living healthy. We are determined as a starting point to put Nigeria in the international map of tourism as we did with Access Lagos Marathon last year. Many people now see Lagos as a tourist centre.”“The Games also help us to build good brotherliness and togetherness among our staff. It is going to part of our corporate calendar. This is the first edition of the Access Games and we hope to sustain it as part of our contribution to sports development and healthy living,” he said.Share this:FacebookRedditTwitterPrintPinterestEmailWhatsAppSkypeLinkedInTumblrPocketTelegram Access Bank GMD/CEO, Herbert Wigwe has commended the team spirit displayed by all the participants at the maiden edition of the Access Games at the Teslim Balogun, Surulere, Lagos on Sunday.Wigwe said that the Games aside from keeping staffers fit, is also aimed at fostering good relationship among bankers.“It’s a game that has several activities and it is for the whole country with different houses that are competing among themselves. It is one way to build our team spirit in the bank but it is not just about our staff, we also engage our friends and customers.last_img read more

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LeBron James: ‘There’s nothing I need to get in this league that I don’t already have’

first_img“The suspense and the excitement around the trade deadline is always kind of pretty crazy,” James said. “Sometimes things happen where guys and players and teams exchange players, and sometimes it don’t happen. But the conversations and the speculation is always there every year.”Los Angeles enters play Thursday in 10th in the Western Conference with a 27-27 record. James’ resume includes three NBA championships and Finals MVPs, four Most Valuable Player awards, 15 All-Star appearances as well as Rookie of the Year honors in 2004.While he might not “need” anything, the Lakers did join in on the trade deadline action. Los Angeles acquired forward Mike Muscala from the Clippers for Michael Beasley and Ivica Zubac, according to ESPN. It also dealt for forward Reggie Bullock. NBA trade deadline: Lakers acquire Mike Muscala from Clippers for Michael Beasley, Ivica Zubac Lonzo Ball celebrates after Lakers don’t trade him at deadlinecenter_img There’s nothing LeBron James needs from the NBA.The Lakers star told reporters anything else he accomplishes in his illustrious career “is just icing on the cake.” The comments came ahead of the trade deadline on Thursday’s shootaround at TD Garden. “There’s nothing I need to get in this league that I don’t already have,” James told Masslive.com. “I love the process of everything I go through to be able to compete every single night and put teams in position to compete for championships.”But there’s nothing I’m chasing or feel like I need to end my career on.” Related Newslast_img read more

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